The question is simply which 1 game from each system would you have liked to see cross pollinate each other.
This idea arose from the recent Metroid Likes thread where the OP asked whether there were any similar games to Metroid on the Genesis. The answer was essentially No, with Chakan being the closest out of all the distant cousins.
Keeping matters 16 bit, this got me to thinking how much both Chakan and Super Metroid would have benefited from each other's influence at the drawing stage. Both are very good games when played with patience, heavy on atmosphere and with an intention to be epic. However, Super Metroid has nothing but shapeless little 'levels' and its backtracking nature comes off as less expansive than trivial. Chakan, on the other hand, is just too hard, to the degree that it makes us question his legend: if Chakan's the greatest warrior of all time, what does that make the rat who just killed him?
Chakan would have lent Super Metroid definite level design, grit, and a sense of magnitude.
Super Metroid would have lent Chakan fluidity, moving speed, and accessibility.
Their union would have made a damned great game.
So which 1 Genesis and 1 Super Nintendo game would you have liked to see cross pollinate each other?